Markus M Lerch Selected Research

Trypsinogen

9/2020	Next generation sequencing pitfalls in diagnosing trypsinogen (PRSS1) mutations in chronic pancreatitis.
5/2020	Early trypsin activation develops independently of autophagy in caerulein-induced pancreatitis in mice.
4/2019	Etiology and Risk Factors of Acute and Chronic Pancreatitis.
1/2019	Genetics, Cell Biology, and Pathophysiology of Pancreatitis.
10/2018	Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis.
1/2018	Cathepsin D regulates cathepsin B activation and disease severity predominantly in inflammatory cells during experimental pancreatitis.
1/2018	Cathepsin B-Mediated Activation of Trypsinogen in Endocytosing Macrophages Increases Severity of Pancreatitis in Mice.
11/2016	Chronic Pancreatitis in the 21st Century - Research Challenges and Opportunities: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop.
7/2016	Cathepsin B Activity Initiates Apoptosis via Digestive Protease Activation in Pancreatic Acinar Cells and Experimental Pancreatitis.
11/2015	Lysosome associated membrane proteins maintain pancreatic acinar cell homeostasis: LAMP-2 deficient mice develop pancreatitis.

For more, sign up at right for free...

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Markus M Lerch Research Topics

Disease

79	Pancreatitis 03/2022 - 02/2002
39	Chronic Pancreatitis 03/2022 - 11/2003
33	Pancreatic Neoplasms (Pancreatic Cancer) 11/2021 - 04/2003
23	Neoplasms (Cancer) 04/2022 - 06/2002
17	Adenocarcinoma 04/2022 - 04/2003
14	Inflammation (Inflammations) 03/2022 - 02/2004
11	Hereditary pancreatitis 07/2020 - 02/2002
10	Autoimmune Pancreatitis 05/2022 - 06/2007
10	Type 2 Diabetes Mellitus (MODY) 01/2022 - 07/2015
9	Gallstones (Gallstone) 01/2021 - 04/2003
8	Fibrosis (Cirrhosis) 12/2015 - 06/2007
7	Pain (Aches) 03/2021 - 01/2004
7	Necrosis 01/2021 - 12/2004
6	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2022 - 02/2010
6	Diabetes Mellitus 01/2020 - 01/2014
6	Acute Necrotizing Pancreatitis 12/2018 - 04/2003
5	Cystic Fibrosis (Mucoviscidosis) 01/2021 - 06/2006
5	Cholelithiasis 01/2019 - 01/2005
4	Disease Progression 01/2022 - 09/2016
4	Body Weight (Weight, Body) 02/2021 - 07/2012
4	Obesity 02/2021 - 02/2010
4	Pancreatic Pseudocyst 12/2018 - 03/2008
4	Obstructive Jaundice (Cholestatic Jaundice) 01/2014 - 01/2010
4	Neoplasm Metastasis (Metastasis) 06/2012 - 10/2003
3	Glucose Intolerance 01/2022 - 01/2021
3	Iron Overload 01/2022 - 01/2017
3	Cardiovascular Diseases (Cardiovascular Disease) 10/2021 - 05/2014
3	Infections 01/2021 - 10/2005
2	Autoimmune Diseases (Autoimmune Disease) 05/2022 - 01/2019
2	Sarcoma (Soft Tissue Sarcoma) 04/2022 - 04/2022
2	Weight Loss (Weight Reduction) 02/2021 - 07/2012

Drug/Important Bio-Agent (IBA)

26	TrypsinogenIBA 09/2020 - 02/2002
18	Peptide Hydrolases (Proteases)FDA Link 01/2021 - 11/2003
17	Proteins (Proteins, Gene)FDA Link 04/2022 - 04/2003
17	CeruletideIBA 01/2021 - 10/2005
16	TrypsinIBA 01/2021 - 02/2002
16	EnzymesIBA 01/2021 - 03/2003
10	Kazal Pancreatic Trypsin InhibitorIBA 03/2022 - 12/2004
10	Lipase (Acid Lipase)FDA Link 01/2017 - 02/2004
9	Biomarkers (Surrogate Marker)IBA 01/2022 - 01/2013
9	Cathepsin BIBA 11/2019 - 06/2002
8	Immunoglobulin G (IgG)IBA 01/2018 - 06/2007
8	SteroidsIBA 01/2017 - 06/2007
7	Fluorouracil (Carac)FDA LinkGeneric 01/2022 - 09/2010
6	Glucose (Dextrose)FDA LinkGeneric 01/2022 - 10/2011
6	CytokinesIBA 01/2021 - 06/2006
6	Enzyme Precursors (Zymogens)IBA 11/2019 - 02/2002
6	Pharmaceutical PreparationsIBA 10/2019 - 04/2010
6	Anti-Bacterial Agents (Antibiotics)IBA 03/2012 - 04/2003
5	Messenger RNA (mRNA)IBA 11/2021 - 04/2003
5	IronIBA 01/2021 - 12/2011
5	CalciumIBA 10/2020 - 02/2002
5	C-Reactive ProteinIBA 01/2018 - 12/2003
4	Leucovorin (Folinic Acid)FDA Link 01/2022 - 09/2010
4	Gemcitabine FDA Link 11/2021 - 09/2010
4	Bile Acids and Salts (Bile Acids)IBA 01/2021 - 02/2010
4	InflammasomesIBA 10/2020 - 06/2014
4	Amylases FDA Link 05/2020 - 02/2004
4	Pancreatic Elastase (Elastase)IBA 01/2020 - 01/2016
4	Cadherins (E-Cadherin)IBA 11/2019 - 04/2003
4	Small Interfering RNA (siRNA)IBA 11/2016 - 04/2003
4	Taurocholic Acid (Sodium Taurocholate)IBA 09/2016 - 08/2006
4	Peroxidase (Myeloperoxidase)IBA 09/2016 - 03/2003
4	AntibodiesIBA 01/2016 - 06/2002
4	Ethanol (Ethyl Alcohol)IBA 07/2015 - 11/2003
3	Proton Pump InhibitorsIBA 07/2021 - 03/2008
3	Insulin (Novolin)FDA Link 02/2021 - 01/2017
3	Blood Group Antigens (Blood Groups)IBA 01/2021 - 04/2015
3	Leukocyte Elastase (Neutrophil Elastase)IBA 11/2019 - 10/2005
3	SmokeIBA 04/2019 - 01/2010
3	Protease Inhibitors (Protease Inhibitor)IBA 01/2019 - 10/2005
3	Amino Acids FDA Link 10/2018 - 10/2005
3	Cathepsin LIBA 01/2018 - 02/2010
3	Biological ProductsIBA 09/2017 - 09/2013
3	Galactoside 2-alpha-L-fucosyltransferase (Fucosyltransferase 2)IBA 02/2016 - 04/2015
3	Phosphotransferases (Kinase)IBA 01/2016 - 02/2012
3	SecretagoguesIBA 06/2015 - 11/2003
3	Lactic Acid (Lactate)FDA LinkGeneric 06/2014 - 08/2006
3	Azathioprine (Imuran)FDA LinkGeneric 01/2014 - 04/2010
3	Cholecystokinin (Pancreozymin)IBA 06/2013 - 11/2003
3	salicylhydroxamic acid (SHAM)IBA 12/2009 - 08/2006
2	Peptides (Polypeptides)IBA 05/2022 - 01/2016
2	RNA (Ribonucleic Acid)IBA 04/2022 - 09/2010
2	Irinotecan (Camptosar)FDA LinkGeneric 01/2022 - 10/2016
2	Cetuximab (Erbitux)FDA Link 01/2022 - 10/2016
2	Bevacizumab (Avastin)FDA Link 01/2022 - 10/2016
2	AntioxidantsIBA 03/2021 - 01/2011

Therapy/Procedure

14	Therapeutics 01/2021 - 01/2006
8	Injections 01/2021 - 08/2008
5	Ligation 12/2020 - 03/2003
5	Adjuvant Chemotherapy 11/2019 - 09/2010
5	Length of Stay 12/2017 - 10/2010
5	Enteral Nutrition (Feeding, Tube) 10/2010 - 04/2003
4	Cholecystectomy 01/2021 - 01/2005
4	Parenteral Nutrition 01/2016 - 12/2003
3	Drug Therapy (Chemotherapy) 01/2021 - 01/2007
3	Intraperitoneal Injections 01/2020 - 06/2015
3	Stents 12/2018 - 12/2013
3	Epidural Analgesia 12/2009 - 08/2006
2	Transplantation 01/2021 - 04/2009